HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → 1-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 5-Benzyl-1-oxa-5-azaspiro[2.4]heptane | HCID 11194805 | — |
| Product | 1-Benzyl-3-ethylaminomethyl-3-hydroxypyrrolidine | HCID 14578452 | — |
Reaction Steps
10.2 g (53.9 mmol) of 5-benzyl-5-aza-1-oxaspiro-[2,4]heptane are added dropwise to 60 ml of aqueous ethylamine solution (50%) and the mixture is stirred overnight at room temperature. The batch is then concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05453422 |
| Source dataset | uspto-grants-1995_09 |
| ORD ID | ord-5ad06185ef514c8b814da9835bd1dce6 |
| Source note | uspto-grants-1995_09 |