HCID 14578460, compound → HCID 14578463, compound

HRID 2400065Notes

Reaction equation

HRID 2400065 reaction equation
[NH2:1][CH2:2][C:3]1([OH:13])[CH2:8][CH2:7][CH2:6][N:5](C(OC)=O)[CH2:4]1>O>[NH2:1][CH2:2][C:3]1([OH:13])[CH2:8][CH2:7][CH2:6][NH:5][CH2:4]1

Participants

3

Reactant 1

HCID 14578460HCID 14578460, compound

Product 1

HCID 14578463HCID 14578463, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.1 g (27.1 mmol) of methyl 3-aminomethyl-3-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 15.8 g of Ba(OH)2 . 8H2O in 150 ml water. The product is filtered off from BaCO3 with suction and concentrated. The residue is boiled five times using 70 ml of dioxane each time, and the dioxane solutions are concentrated and distilled.

Workup

  1. filtrationThe product is filtered off from BaCO3 with suction
  2. concentrationconcentrated
  3. concentrationthe dioxane solutions are concentrated
  4. distillationdistilled

Sources & evidence

ORD record
ord-583f69cb264346d68ddd98b5047b881e
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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