HCID 14578460, compound → HCID 14578463, compound

Participants

Reaction Steps

5.1 g (27.1 mmol) of methyl 3-aminomethyl-3-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 15.8 g of Ba(OH)2 . 8H2O in 150 ml water. The product is filtered off from BaCO3 with suction and concentrated. The residue is boiled five times using 70 ml of dioxane each time, and the dioxane solutions are concentrated and distilled.

Provenance & Evidence