2,2-Dimethyl-1,3-dioxane-4,6-dione → 8-Trifluoromethoxy-3-carboxy-coumarin

Participants

Reaction Conditions

Reaction Steps

3-(Trifluoromethoxy)salicylaldehyde (0.250 g, 1.21 mmol) and Meldrum's acid (0.200 g, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 0.197 g of 8-(trifluoromethoxy)-3-carboxy-coumarin in a 60% yield: LCMS (ESI) m/z 275 (MH+).

Provenance & Evidence