2,2-Dimethyl-1,3-dioxane-4,6-dione → 8-Trifluoromethoxy-3-carboxy-coumarin

HRID 240011노트

반응식

HRID 240011 반응식
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:6]([CH:7]=O)[C:5]=1[OH:12].CC1(C)O[C:21](=[O:22])[CH2:20][C:18](=[O:19])[O:17]1>O>[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:6]2[C:5]=1[O:12][C:21](=[O:22])[C:20]([C:18]([OH:19])=[O:17])=[CH:7]2

참가 물질

4

반응물 2

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 27792702-Hydroxy-3-(trifluoromethoxy)benzaldehyde

생성물 1

HCID 866503588-Trifluoromethoxy-3-carboxy-coumarin수율 60%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
75 °C

실험 절차

3-(Trifluoromethoxy)salicylaldehyde (0.250 g, 1.21 mmol) and Meldrum's acid (0.200 g, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 0.197 g of 8-(trifluoromethoxy)-3-carboxy-coumarin in a 60% yield: LCMS (ESI) m/z 275 (MH+).

후처리

  1. temperatureAfter cooling to room temperature
  2. filtrationthe precipitate was filtered
  3. customdried at suction

출처 및 근거

ORD 기록
ord-f0567159728c40d0b437e4db81ad0cb9
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642788B2

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