反应详情

A solution of (4-hydroxy-2-mercapto-6-methyl-5-pyrimidinyl)-acetic acid (190 g, 0.95 mol) and concentrated sulfuric acid (50 ml) in methanol (1.51) is refluxed for 18 hours. The suspension is cooled and filtered to give methyl(4-hydroxy-2-mercapto-6-methyl-5-pyrimidinyl)-acetate (160 g, 79%).

1. temperatureThe suspension is cooled
2. filtrationfiltered