3,5-Dimethyl-1H-pyrazole-1-carboxamidine mononitrate → HCID 86749010, compound

HRID 2400153Notes

Reaction equation

HRID 2400153 reaction equation
F[B-](F)(F)F.[O:6]=[N+:7]=[O:8].[N+:9]([O-:12])([OH:11])=[O:10].[CH3:13][C:14]1[CH:18]=[C:17]([CH3:19])[N:16]([C:20]([NH2:22])=[NH:21])[N:15]=1>C(#N)C>[N+:9]([O-:12])([OH:11])=[O:10].[CH3:13][C:14]1[C:18]([N+:7]([O-:8])=[O:6])=[C:17]([CH3:19])[N:16]([C:20]([NH2:22])=[NH:21])[N:15]=1

Participants

4

Reactant 2

HCID 1981863,5-Dimethyl-1H-pyrazole-1-carboxamidine mononitrateHCID 11073463Nitronium tetrafluoroborate

Product 1

HCID 86749010HCID 86749010, compoundYield 98.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2 g of nitronium tetrafluoroborate were added little by little to a suspension of 2.01 g of 3,5-dimethyl-1H-pyrazole-1-carboxamidine nitrate in 150 ml of absolute acetonitrile, with cooling with ice in argon atmosphere, and the reaction mixture was stirred for 30 minutes with cooling with ice. The solvent was removed by distillation under reduced pressure, and the residue was washed with chloroform to obtain 2.43 g of 3,5-dimethyl-4-nitro-1H-pyrazole-1-carboxamidine nitrate.

Workup

  1. temperaturewith cooling with ice in argon atmosphere
  2. temperaturewith cooling with ice
  3. customThe solvent was removed by distillation under reduced pressure
  4. washthe residue was washed with chloroform

Sources & evidence

ORD record
ord-8aad335e205b4f30aaae0ed053e04fac
Source dataset
uspto-grants-1995_09
Patent number
US05453514

Reaction notes

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