反应详情

To a solution of 2-(6-Methyl-2-pyridyl)imidazole (2.16 g) and sodium t-butoxide (1.57 g) in 50 mL dry DMF was added N-(6-bromohexyl)phthalimide (4.72 g). The resulting solution was stirred at room temperature for 3 h and then at 60° C. for 3.5 h. The solution was poured into H2O (80 mL) and then extracted three times with EtOAc (3×100 mL). The combined EtOAc extract was dried with anhydrous Na2SO4, and then evaporated to dryness. The product was purified by a silica gel column using EtOAc as the eluent. Yield: about 4.2 g.

1. waitat 60° C. for 3.5 h
2. extractionextracted three times with EtOAc (3×100 mL)
3. extractionThe combined EtOAc extract
4. dry with materialwas dried with anhydrous Na2SO4
5. customevaporated to dryness
6. customThe product was purified by a silica gel column