HRID2400309

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC(C)(C)OC(=O)c1ccc(CCCCCCCCCCCC(=O)N[C@@H](CCC(=O)OCc2ccccc2)C(=O)OC(C)(C)C)cc1

HCID68944872

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)(C)OC(=O)c1ccc(CCCCCCCCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)OC(C)(C)C)cc1

HCID68944855

未命名化合物

收率 98.9%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

(S)-2-[12-(4-tert-Butoxycarbonylphenyl) dodecanoylamino]pentanedioic acid 5-benzyl ester 1-tert-butyl ester (175 mg, 0.27 mmol) was dissolved in THF and placed under nitrogen. 10% palladium on carbon (ca. 20 mg) was added, and the flask was evacuated and filled with nitrogen three times. The flask was equipped with balloon filled with hydrogen, and stirred at rt overnight. The solution was filtered through celite, washing with THF. The filtrate was concentrated under vacuum to yield an oil (0.15 g).

WORKUP

后处理

customthe flask was evacuated
additionfilled with nitrogen three times
customThe flask was equipped with balloon
additionfilled with hydrogen
filtrationThe solution was filtered through celite
washwashing with THF
concentrationThe filtrate was concentrated under vacuum

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-43a71c3e58214876a49724da930a0bd3
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08796205B2
来源说明: uspto-grants-2014_08

反应SMILES

[C:1]([O:5][C:6](=[O:47])[C@@H:7]([NH:20][C:21](=[O:46])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]1[CH:38]=[CH:37][C:36]([C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])=[CH:35][CH:34]=1)[CH2:8][CH2:9][C:10]([O:12]CC1C=CC=CC=1)=[O:11])([CH3:4])([CH3:3])[CH3:2]>C1COCC1.[Pd]>[C:1]([O:5][C:6](=[O:47])[C@@H:7]([NH:20][C:21](=[O:46])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]1[CH:34]=[CH:35][C:36]([C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])=[CH:37][CH:38]=1)[CH2:8][CH2:9][C:10]([OH:12])=[O:11])([CH3:4])([CH3:2])[CH3:3]