Acetyl chloride → HCID 68163043, compound

HRID 2400336Notes

Reaction equation

HRID 2400336 reaction equation
Cl.[NH:2]1[CH2:5][CH:4]([N:6]2[CH:10]=[C:9]([Br:11])[CH:8]=[N:7]2)[CH2:3]1.[C:12](Cl)(=[O:14])[CH3:13]>C(Cl)Cl>[Br:11][C:9]1[CH:8]=[N:7][N:6]([CH:4]2[CH2:5][N:2]([C:12](=[O:14])[CH3:13])[CH2:3]2)[CH:10]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 670275871201657-76-2

Product 1

HCID 68163043HCID 68163043, compoundYield 89.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 1-Azetidin-3-yl-4-bromo-1H-pyrazole hydrochloride (0.3 g, 1.26 mmol) in CH2Cl2 (15 ml) added ET3N (0.47 ml) and acetyl chloride (0.107 ml, 1.5 mmol) stirred at RT for 2 hours then partitioned between EtOAc and H2O. The organic layer was separated, washed with water H2O, dried over MgSO4, filtered and concentrated under reduced pressure to give the product (276 mg).

Workup

  1. customthen partitioned between EtOAc and H2O
  2. customThe organic layer was separated
  3. washwashed with water H2O
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-e1269fd6d78747b69a9b26fa45529940
Source dataset
uspto-grants-2014_08
Patent number
US08796244B2

Reaction notes

Loading…