Acetyl chloride → HCID 68163043, compound

Participants

Reaction Steps

To 1-Azetidin-3-yl-4-bromo-1H-pyrazole hydrochloride (0.3 g, 1.26 mmol) in CH2Cl2 (15 ml) added ET3N (0.47 ml) and acetyl chloride (0.107 ml, 1.5 mmol) stirred at RT for 2 hours then partitioned between EtOAc and H2O. The organic layer was separated, washed with water H2O, dried over MgSO4, filtered and concentrated under reduced pressure to give the product (276 mg).

Provenance & Evidence