4,6-Dichloropyrimidine → HCID 86669124, compound

HRID 2400338Notes

Reaction equation

HRID 2400338 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16]>CO>[C:15]([O:14][C:13](=[O:19])[NH:12][CH2:11][CH2:10][NH:9][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1)([CH3:18])([CH3:16])[CH3:17]

Participants

4

Reactant 2

HCID 709434,6-DichloropyrimidineHCID 187201N-BOC-ethylenediamine

Product 1

HCID 86669124HCID 86669124, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 4,6-dichloropyrimidine (0.533 g, 35.8 mmol) in MeOH (15 ml) was added tert-butyl N-(2-aminoethyl)carbamate and the reaction stirred at room temperature for 6.5 hours. Reaction concentrated in vacuo, solids triturated with EtOAc/petrol. Filtrate which contains the desired product was concentrated and EtOAc and sat. NaHCO3 added.

Workup

  1. customReaction
  2. concentrationconcentrated in vacuo, solids
  3. customtriturated with EtOAc/petrol
  4. concentrationwas concentrated
  5. additionEtOAc and sat. NaHCO3 added

Sources & evidence

ORD record
ord-1455d12ba553437cbde309095ab95212
Source dataset
uspto-grants-2014_08
Patent number
US08796244B2

Reaction notes

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