Hydrochloric Acid → 4-(4-bromo-1H-pyrazol-1-yl)piperidine hydrochloride

HRID 2400347Notes

Reaction equation

HRID 2400347 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:18]=[C:17]([Br:19])[CH:16]=[N:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:20]>>[ClH:20].[Br:19][C:17]1[CH:16]=[N:15][N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:18]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 45480278tert-Butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate

Product 1

HCID 534078484-(4-bromo-1H-pyrazol-1-yl)piperidine hydrochloride

Procedure

To 4-(4-Bromo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (1 g, 3. mmol) in ETOAc (4 ml) was added sat. ETOAc in HCl (5 ml) and the reaction mixture stirred at room temperature for 2 h. The solvent removed in vacuo and re-evaporated with toluene to give the product (0.68 g), which was used without further purification MS: [M+H]+=230

Workup

  1. customThe solvent removed in vacuo
  2. customre-evaporated with toluene

Sources & evidence

ORD record
ord-40a94be407944130ab38d012d3899389
Source dataset
uspto-grants-2014_08
Patent number
US08796244B2

Reaction notes

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