Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | HCID 68162667 | HCID 68162667 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68163058 | HCID 68163058 | 18.2% |
Reaction Steps
2-[2-(3-{3-[3-(2,2,2-Trifluoro-ethyl)-ureido]-phenyl}-imidazo[1,2-a]pyridin-7-yl)-pyrimidin-4-yl]-imidazole-1-sulfonic acid dimethylamide (140 mg, 0.23 mmol) dissolved in EtOH (5 ml) and MeOH(1 ml) treated with 2M HCl (1 ml) heated at 60° C. for 2 hours. Reaction mixture concentrated under reduced pressure and was purified by preparative HPLC to give product (20 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08796244B2 |
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| Source dataset | uspto-grants-2014_08 |
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| ORD ID | ord-c45f3ff67eef47bdb1560de2383da1ca |
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| Source note | uspto-grants-2014_08 |
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