Hydrochloric Acid → HCID 68163058, compound

HRID 2400348Notes

Reaction equation

HRID 2400348 reaction equation
CN(C)S([N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([C:17]2[CH:22]=[CH:21][N:20]3[C:23]([C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([NH:32][C:33]([NH:35][CH2:36][C:37]([F:40])([F:39])[F:38])=[O:34])[CH:27]=4)=[CH:24][N:25]=[C:19]3[CH:18]=2)[N:12]=1)(=O)=O.CO.Cl>CCO>[NH:6]1[CH:10]=[CH:9][N:8]=[C:7]1[C:11]1[CH:16]=[CH:15][N:14]=[C:13]([C:17]2[CH:22]=[CH:21][N:20]3[C:23]([C:26]4[CH:27]=[C:28]([NH:32][C:33]([NH:35][CH2:36][C:37]([F:38])([F:40])[F:39])=[O:34])[CH:29]=[CH:30][CH:31]=4)=[CH:24][N:25]=[C:19]3[CH:18]=2)[N:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 68162667HCID 68162667, compound

Product 1

HCID 68163058HCID 68163058, compoundYield 18.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

2-[2-(3-{3-[3-(2,2,2-Trifluoro-ethyl)-ureido]-phenyl}-imidazo[1,2-a]pyridin-7-yl)-pyrimidin-4-yl]-imidazole-1-sulfonic acid dimethylamide (140 mg, 0.23 mmol) dissolved in EtOH (5 ml) and MeOH(1 ml) treated with 2M HCl (1 ml) heated at 60° C. for 2 hours. Reaction mixture concentrated under reduced pressure and was purified by preparative HPLC to give product (20 mg).

Workup

  1. customReaction mixture
  2. concentrationconcentrated under reduced pressure
  3. customwas purified by preparative HPLC

Sources & evidence

ORD record
ord-c45f3ff67eef47bdb1560de2383da1ca
Source dataset
uspto-grants-2014_08
Patent number
US08796244B2

Reaction notes

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