反应详情

Hydrazine hydrate (80% in water, 0.25 ml, 2 equiv) was added to a mixture of imidazo[1,2-a]pyridine-7-carboximidic acid methyl ester hydrochloride (1.0 g, 4.7 mmol, 1 equiv) in methanol (30 ml). The mixture was heated to 70 deg C. for 1 hour then allowed to cool to room temperature. After leaving to stand overnight, any solid was removed by vacuum filtration and the solution was concentrated in vacuo and re-concentrated from methanol and was used crude without further purification in the cyclisation step

1. temperatureThe mixture was heated to 70 deg C
2. customAfter leaving
3. waitto stand overnight
4. customany solid was removed by vacuum filtration
5. concentrationthe solution was concentrated in vacuo
6. concentrationre-concentrated from methanol
7. customwithout further purification in the cyclisation step