HCID 59626713, compound → HCID 68784471, compound

HRID 2400376Notes

Reaction equation

HRID 2400376 reaction equation
[Cl:1][C:2]1[C:10]2[NH:9][N:8]=[CH:7][C:6]=2[C:5]2[CH2:11][N:12]3[C:26]([C:27]([OH:30])([CH3:29])[CH3:28])=[CH:25][N:24]=[C:13]3[CH:14]([NH:16]C(=O)OC(C)(C)C)[CH2:15][C:4]=2[CH:3]=1>C(OCC)(=O)C>[ClH:1].[NH2:16][CH:14]1[C:13]2=[N:24][CH:25]=[C:26]([C:27]([OH:30])([CH3:28])[CH3:29])[N:12]2[CH2:11][C:5]2[C:6]3[CH:7]=[N:8][NH:9][C:10]=3[C:2]([Cl:1])=[CH:3][C:4]=2[CH2:15]1

Participants

3

Reactant 1

HCID 59626713HCID 59626713, compound

Product 1

HCID 68784471HCID 68784471, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl [4-chloro-10-(1-hydroxy-1-methylethyl)-3,6,7,12-tetrahydroimidazo[1′,2′:1,7]azepino[3,4-e]indazol-7-yl]carbamate from Step F in Ethyl acetate (50 mL) was cooled to 0° C. HCl gas was bubbled into the solution until saturated and the reaction allowed to warm slowly to room temperature. The reaction was concentrated at reduced pressure and dried to give a quantitative yield of the title compound. MS: m/z 331 (M+1).

Workup

  1. customHCl gas was bubbled into the solution until saturated and the reaction
  2. concentrationThe reaction was concentrated at reduced pressure
  3. customdried

Sources & evidence

ORD record
ord-2a3e27e025e444ce8e1ccf5e001704fb
Source dataset
uspto-grants-2014_08
Patent number
US08796260B2

Reaction notes

Loading…