Pyrrolidine → HCID 66747407, compound

HRID 2400448Notes

Reaction equation

HRID 2400448 reaction equation
[CH3:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[F:16])[N:12]=[C:11]([N:17]1[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]1)[NH:10][C:9]2=O.[NH:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1>>[CH3:32][C:28]1[CH:29]=[CH:30][CH:31]=[C:2]([CH3:1])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[F:16])[N:12]=[C:11]([N:17]1[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]1)[N:10]=[C:9]2[N:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 136387802HCID 136387802, compound

Product 1

HCID 66747407HCID 66747407, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-((2,6-dimethylbenzyl)amino)-7-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and pyrrolidine in step E. MS (ESI): predicted mass calcd. for C25H25FN6O2, 460.2

Sources & evidence

ORD record
ord-0633bfb6401b497db649225500a18183
Source dataset
uspto-grants-2014_08
Patent number
US08796263B2

Reaction notes

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