Pyrrolidine → HCID 66747029, compound

HRID 2400460Notes

Reaction equation

[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[NH:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([O:19]CC)=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[CH:23]([CH3:25])[CH3:24].[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)=[N:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[CH:23]([CH3:24])[CH3:25]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 136379411HCID 136379411, compound

Product 1

HCID 66747029HCID 66747029, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(7-fluoro-6-isopropyl-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and pyrrolidine in step E. MS (ESI): predicted mass calcd. for C19H20FN5O2, 369.2

Sources & evidence

ORD record: ord-28905dc821b74aef86d853444f59f317
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796263B2

Reaction notes

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