Pyrrolidine → HCID 66747498, compound

HRID 2400490Notes

Reaction equation

HRID 2400490 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[NH:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([O:19]CC)=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1.[NH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)=[N:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 136379421HCID 136379421, compound

Product 1

HCID 66747498HCID 66747498, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(7-chloro-4-oxo-6-(piperidin-1-yl)-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and pyrrolidine in step E. MS (ESI): predicted mass calcd. for C21H23ClN6O2, 410.2

Sources & evidence

ORD record
ord-90e271139c8b40028658cf1980824ec4
Source dataset
uspto-grants-2014_08
Patent number
US08796263B2

Reaction notes

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