Pyrrolidine → HCID 66747751, compound

HRID 2400502Notes

Reaction equation

HRID 2400502 reaction equation
[C:1]1([CH3:28])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([N:17]1[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]1)[NH:11][C:10]2=O.[NH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>>[N:29]1([C:10]2[C:9]3[C:14](=[CH:15][CH:16]=[C:7]([C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=4[CH3:28])[CH:8]=3)[N:13]=[C:12]([N:17]3[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]3)[N:11]=2)[CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 136337162HCID 136337162, compound

Product 1

HCID 66747751HCID 66747751, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-(o-tolyl)-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and pyrrolidine in step E. MS (ESI/CI): predicted mass C23H21N5O2, 399.2.

Sources & evidence

ORD record
ord-7da1eb3822174ae6895d2d2e8bf96743
Source dataset
uspto-grants-2014_08
Patent number
US08796263B2

Reaction notes

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