Pyrrolidine → HCID 66747752, compound

HRID 2400514Notes

Reaction equation

HRID 2400514 reaction equation
[CH3:1][C:2]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:3]=1[O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[CH3:15])[N:11]=[C:10]([N:16]1[CH:20]=[C:19]([C:21]([O:23]CC)=[O:22])[CH:18]=[N:17]1)[NH:9][C:8]2=O.[NH:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH3:1][C:2]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:3]=1[O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[CH3:15])[N:11]=[C:10]([N:16]1[CH:20]=[C:19]([C:21]([OH:23])=[O:22])[CH:18]=[N:17]1)[N:9]=[C:8]2[N:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 136337160HCID 136337160, compound

Product 1

HCID 66747752HCID 66747752, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-(2,6-dimethylphenoxy)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and pyrrolidine in step E. MS (ESI/CI): predicted mass C25H25N5O3, 443.2.

Sources & evidence

ORD record
ord-7f3632d07f164e088745b0afa6ad8530
Source dataset
uspto-grants-2014_08
Patent number
US08796263B2

Reaction notes

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