HCID 123988195, compound → HCID 90228697, compound

HRID 2400748Notes

Reaction equation

HRID 2400748 reaction equation
[C:1]([O:5][C:6](=[O:33])[NH:7][C@H:8]([CH3:32])[C:9]([NH:11][NH:12][C:13]([C@@H:15]1[CH2:21][CH2:20][C@@H:19]2[CH2:22][N:16]1[C:17](=[O:31])[N:18]2[O:23]CC1C=CC=CC=1)=[O:14])=[O:10])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6](=[O:33])[NH:7][C@H:8]([CH3:32])[C:9]([NH:11][NH:12][C:13]([C@@H:15]1[CH2:21][CH2:20][C@@H:19]2[CH2:22][N:16]1[C:17](=[O:31])[N:18]2[OH:23])=[O:14])=[O:10])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 123988195HCID 123988195, compound

Product 1

HCID 90228697HCID 90228697, compoundYield 100.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of compound 275 (400 mg, 0.86 mmol) in 30 mL of MeOH was added 0.8 g of Pd/C (10%, wet). The mixture was hydrogenated at room temperature for 2 h. The catalyst was removed by filtration through a celite pad. The filtrate was concentrated to afford compound 276 as a colorless gum (320 mg, 99%).

Workup

  1. customThe catalyst was removed by filtration through a celite pad
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-05e4e6e8f2e94c03a34d40bf8dd07428
Source dataset
uspto-grants-2014_08
Patent number
US08796257B2

Reaction notes

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