HCID 131731727, compound → HCID 90228699, compound

HRID 2400753Notes

Reaction equation

HRID 2400753 reaction equation
[C:1]([O:5][C:6](=[O:36])[NH:7][C@@H:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13]([NH:15][NH:16][C:17]([C@@H:19]1[CH2:25][CH2:24][C@@H:23]2[CH2:26][N:20]1[C:21](=[O:35])[N:22]2[O:27]CC1C=CC=CC=1)=[O:18])=[O:14])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6](=[O:36])[NH:7][C@@H:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13]([NH:15][NH:16][C:17]([C@@H:19]1[CH2:25][CH2:24][C@@H:23]2[CH2:26][N:20]1[C:21](=[O:35])[N:22]2[OH:27])=[O:18])=[O:14])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 131731727HCID 131731727, compound

Product 1

HCID 90228699HCID 90228699, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of compound 286 (0.22 g, 0.44 mmol) in 10 mL of CH3OH was added 0.1 g of Pd—C (10%, wet). The mixture was hydrogenated at room temperature for 16 h. The catalyst was removed by filtration through a pad of celite. The filtrate was concentrated to afford compound 287 as a solid (0.15 g, 83%).

Workup

  1. customThe catalyst was removed by filtration through a pad of celite
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-99da7805437d40f687a8703b223d5950
Source dataset
uspto-grants-2014_08
Patent number
US08796257B2

Reaction notes

Loading…