Iodoethane → HCID 58530434, compound

HRID 2400787Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:32]=[CH:31][C:6]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13](/[CH:17]=[C:18]4/[C:19](=[O:30])[N:20]([CH:24]5[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]5)[C:21](=[O:23])[S:22]/4)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[C:5]([C:33]([F:36])([F:35])[F:34])[CH:4]=1.[CH2:37](I)[CH3:38]>>[CH2:37]([N:27]1[CH2:28][CH2:29][CH:24]([N:20]2[C:19](=[O:30])/[C:18](=[CH:17]/[C:13]3[CH:12]=[C:11]4[C:16](=[CH:15][CH:14]=3)[N:8]([CH2:7][C:6]3[CH:31]=[CH:32][C:3]([O:2][CH3:1])=[CH:4][C:5]=3[C:33]([F:35])([F:36])[F:34])[N:9]=[CH:10]4)/[S:22][C:21]2=[O:23])[CH2:25][CH2:26]1)[CH3:38]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 58530475HCID 58530475, compound

Product 1

HCID 58530434HCID 58530434, compound

Procedure

(5Z)-3-(1-Ethylpiperidin-4-yl)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazolidine-2,4-dione was prepared from (5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-piperidin-4-yl-1,3-thiazolidine-2,4-dione (Example 26) and ethyl iodide following General Procedure S.

Sources & evidence

ORD record: ord-bf5c4aa8e1f7408191a315911ace45ff
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796256B2

Reaction notes

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