反应详情

温度

45 °C

A solution of (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-1,3-thiazolidine-2,4-dione (Example 42; 0.1 mmol) in dioxane (3 mL) was treated with 10% aq. HCl (0.5 mL) and stirred at 45° C. overnight. Concentration of the reaction in vacuo gave a pale yellow solid which was triturated with ether to afford pure (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(2,3-dihydroxypropyl)-1,3-thiazolidine-2,4-dione as a pale yellow crystalline solid.

1. customConcentration of the reaction in vacuo
2. customgave a pale yellow solid which
3. customwas triturated with ether