HRID2400870

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3014068

1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride

C8H19Cl3N2

结构：O=C1NC(=O)/C(=C/c2ccc3c(ccn3Cc3ccc(Cl)cc3C(F)(F)F)c2)S1

HCID86659631

未命名化合物

PRODUCTS

生成物

$结构：CN1CCN(CCCN2C(=O)S/C(=C\c3ccc4c(ccn4Cc4ccc(Cl)cc4C(F)(F)F)c3)C2=O)CC1$

HCID58530591

未命名化合物

PROCEDURE

实验过程

(5Z)-5-[(1-{[4-Chloro-2-(trifluoromethyl)phenyl]methyl}-1H-indol-5-yl)methylidene]-3-[3-(4-methylpiperazin-1-yl)propyl]-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)-benzyl]-1H-indol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 243) and 4-(3-chloropropyl)-1-methylpiperazine dihydrochloride following General Procedure H.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d7764aa976a44f2f94735a9f28d035bd
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08796256B2
来源说明: uspto-grants-2014_08

反应 SMILES

[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.Cl.Cl.Cl[CH2:33][CH2:34][CH2:35][N:36]1[CH2:41][CH2:40][N:39]([CH3:42])[CH2:38][CH2:37]1>>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[N:19]([CH2:33][CH2:34][CH2:35][N:36]5[CH2:41][CH2:40][N:39]([CH3:42])[CH2:38][CH2:37]5)[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)=[C:4]([C:26]([F:29])([F:27])[F:28])[CH:3]=1