1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride → (5Z)-5-[(1-{[4-Chloro-2-(trifluoromethyl)phenyl]methyl}-1H-indol-5-yl)methylidene]-3-[3-(4-methylpiperazin-1-yl)propyl]-1,3-thiazolidine-2,4-dione

Participants

Role	Name	HCID	Charge
Reactant	1-(3-Chloropropyl)-4-methylpiperazine dihydrochloride	HCID 3014068	—
Reactant	(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)-benzyl]-1H-indol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine	HCID 86659631	—
Product	(5Z)-5-[(1-{[4-Chloro-2-(trifluoromethyl)phenyl]methyl}-1H-indol-5-yl)methylidene]-3-[3-(4-methylpiperazin-1-yl)propyl]-1,3-thiazolidine-2,4-dione	HCID 58530591	—

Reaction Steps

(5Z)-5-[(1-{[4-Chloro-2-(trifluoromethyl)phenyl]methyl}-1H-indol-5-yl)methylidene]-3-[3-(4-methylpiperazin-1-yl)propyl]-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)-benzyl]-1H-indol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 243) and 4-(3-chloropropyl)-1-methylpiperazine dihydrochloride following General Procedure H.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08796256B2
Source dataset	uspto-grants-2014_08
ORD ID	ord-d7764aa976a44f2f94735a9f28d035bd
Source note	uspto-grants-2014_08