2-Bromoethyl methyl ether → HCID 58530406, compound

HRID 2400874Notes

Reaction equation

HRID 2400874 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.[CH3:30][O:31][CH2:32][CH2:33]Br>>[F:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[N:19]([CH2:33][CH2:32][O:31][CH3:30])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)=[C:4]([C:26]([F:29])([F:27])[F:28])[CH:3]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 86659633HCID 86659633, compound

Product 1

HCID 58530406HCID 58530406, compound

Procedure

(5Z)-5-[(1-{[4-Fluoro-2-(trifluoromethyl)phenyl]methyl}-1H-indol-5-yl)methylidene]-3-[2-(methyloxy)ethyl]-1,3-thiazolidine-2,4-dione was prepared from [(5Z)-5-({1-[4-fluoro-2-(trifluoromethyl)benzyl]-1H-indol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 249) and 2-bromoethyl methyl ether following General Procedure H.

Sources & evidence

ORD record
ord-46780c88fdbb4868b8523960d62b185e
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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