1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde → HCID 86659642, compound

HRID 2400882Notes

Reaction equation

HRID 2400882 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=O)=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[O:27]=[C:28]1[N:32]([C@@H:33]2[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][C@H:34]2[F:46])[C:31](=[O:47])[CH2:30][S:29]1>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11](/[CH:15]=[C:30]3/[C:31](=[O:47])[N:32]([C@@H:33]4[CH2:38][CH2:37][NH:36][CH2:35][C@H:34]4[F:46])[C:28](=[O:27])[S:29]/3)=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

3

Reactant 2

HCID 866545381-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehydeHCID 86659643HCID 86659643, compound

Product 1

HCID 86659642HCID 86659642, compound

Procedure

(5Z)-5-({1-[2,4-Bis(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[trans-3-fluoropiperidin-4-yl]-1,3-thiazolidine-2,4-dione was prepared from [2,4-bis(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 6) and 1,1-dimethylethyl trans-4-(2,4-dioxo-1,3-thiazolidin-3-yl)-3-fluoropiperidine-1-carboxylate (from Example 273) following General Procedure F.

Sources & evidence

ORD record
ord-dbdf59c5e6884bcca9a1048e6914c3eb
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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