1-(4-fluoro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde → HCID 86659652, compound

HRID 2400889Notes

Reaction equation

HRID 2400889 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=O)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1.[O:24]=[C:25]1[N:29]([C@H:30]2[C@H:35]([OH:36])[CH2:34][CH2:33][N:32](C(OC(C)(C)C)=O)[CH2:31]2)[C:28](=[O:44])[CH2:27][S:26]1>>[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:27]4/[C:28](=[O:44])[N:29]([C@H:30]5[C@H:35]([OH:36])[CH2:34][CH2:33][NH:32][CH2:31]5)[C:25](=[O:24])[S:26]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:20]([F:21])([F:23])[F:22])[CH:3]=1

Participants

3

Reactant 2

HCID 866545871-(4-fluoro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehydeHCID 86659650HCID 86659650, compound

Product 1

HCID 86659652HCID 86659652, compound

Procedure

(5Z)-5-({1-[4-Fluoro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-[trans-4-hydroxypiperidin-3-yl]-1,3-thiazolidine-2,4-dione was prepared from [4-fluoro-2-(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 5) and 1,1-dimethylethyl trans-3-(2,4-dioxo-1,3-thiazolidin-3-yl)-4-hydroxy-piperidine-1-carboxylate (from Example 270) following General Procedure F.

Sources & evidence

ORD record
ord-cbd2a465645c40ae8dcdde0d47dce5c8
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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