tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate → HCID 86659658, compound

HRID 2400898Notes

Reaction equation

HRID 2400898 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[NH:19][C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.OC[C@H:32]1[CH2:37][CH2:36][CH2:35][CH2:34][N:33]1[C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39]>>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12](/[CH:16]=[C:17]4/[C:18](=[O:23])[N:19]([CH2:34][C@H:35]5[CH2:36][CH2:37][CH2:32][N:33]5[C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[C:20](=[O:22])[S:21]/4)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:27])([F:29])[F:28])[CH:3]=1

Participants

3

Reactant 2

HCID 6933953tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylateHCID 86659608HCID 86659608, compound

Product 1

HCID 86659658HCID 86659658, compound

Procedure

1,1-Dimethylethyl (2R)-2-[{(5Z)-5-[(1-{[4-chloro-2-(trifluoromethyl)phenyl]-methyl}-1H-indazol-5-yl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}pyrrolidine-1-carboxylate was prepared from (5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine (from Example 1) and 1,1-dimethylethyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate following General Procedure J.

Sources & evidence

ORD record
ord-ca50955b77074648a18a52de34e88517
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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