HRID2400905

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22248400

tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate

C11H20FNO3

结构：O=C1NC(=O)C(=Cc2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)S1

HCID86659657

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(F)(CN2C(=O)SC(=Cc3ccc4c(cnn4Cc4ccc(Cl)cc4C(F)(F)F)c3)C2=O)CC1

HCID86659664

未命名化合物

PROCEDURE

实验过程

4-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-ylmethyl}-4-fluoropiperidine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dione and 4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester following General Procedure J.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-119e93fd348d428ba4952ad9c008baf8
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08796256B2
来源说明: uspto-grants-2014_08

反应 SMILES

[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](=[O:22])[NH:19][C:18]4=[O:23])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.[C:30]([O:34][C:35]([N:37]1[CH2:42][CH2:41][C:40]([F:45])([CH2:43]O)[CH2:39][CH2:38]1)=[O:36])([CH3:33])([CH3:32])[CH3:31]>>[C:30]([O:34][C:35]([N:37]1[CH2:42][CH2:41][C:40]([CH2:43][N:19]2[C:18](=[O:23])[C:17](=[CH:16][C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:24]=[CH:25][C:2]([Cl:1])=[CH:3][C:4]=3[C:26]([F:27])([F:29])[F:28])[N:8]=[CH:9]4)[S:21][C:20]2=[O:22])([F:45])[CH2:39][CH2:38]1)=[O:36])([CH3:33])([CH3:31])[CH3:32]