HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate → 4-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-ylmethyl}-4-fluoropiperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate | HCID 22248400 | — |
| Reactant | 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dione | HCID 86659657 | — |
| Product | 4-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-ylmethyl}-4-fluoropiperidine-1-carboxylic acid tert-butyl ester | HCID 86659664 | — |
Reaction Steps
4-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-ylmethyl}-4-fluoropiperidine-1-carboxylic acid tert-butyl ester was prepared from 5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dione and 4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester following General Procedure J.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796256B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-119e93fd348d428ba4952ad9c008baf8 |
| Source note | uspto-grants-2014_08 |