[4-(2-hydroxyethyl)tetrahydro-2H-pyran-4-yl]carbamic acid tert-butyl ester → [4-(2-{5-[1-(2,4-Bis-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}ethyl)tetrahydro-2H-pyran-4-yl]carbamic acid tert-butyl ester
Reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19](=[O:21])[NH:18][C:17]3=[O:22])=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[C:33]([O:37][C:38](=[O:49])[NH:39][C:40]1([CH2:46][CH2:47]O)[CH2:45][CH2:44][O:43][CH2:42][CH2:41]1)([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38](=[O:49])[NH:39][C:40]1([CH2:46][CH2:47][N:18]2[C:17](=[O:22])[C:16](=[CH:15][C:11]3[CH:10]=[C:9]4[C:14](=[CH:13][CH:12]=3)[N:6]([CH2:5][C:4]3[CH:23]=[CH:24][C:25]([C:27]([F:29])([F:28])[F:30])=[CH:26][C:3]=3[C:2]([F:31])([F:1])[F:32])[N:7]=[CH:8]4)[S:20][C:19]2=[O:21])[CH2:45][CH2:44][O:43][CH2:42][CH2:41]1)([CH3:36])([CH3:35])[CH3:34]Participants
3
Reactant 2
Product 1
Procedure
[4-(2-{5-[1-(2,4-Bis-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}ethyl)tetrahydro-2H-pyran-4-yl]carbamic acid tert-butyl ester was prepared from 5-[1-(2,4-bis-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]thiazolidine-2,4-dione (from Example 6) and ([4-(2-hydroxyethyl)tetrahydro-2H-pyran-4-yl]carbamic acid tert-butyl ester following General Procedure J.
Sources & evidence
- ORD record
- ord-94fc116881be4691bed33c0c617c6db8
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08796256B2
Reaction notes
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