1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde → HCID 86659684, compound

HRID 2400937Notes

Reaction equation

HRID 2400937 reaction equation
[O:1]=[C:2]1[N:6]([C@H:7]2[C@H:12]([OH:13])[CH2:11][CH2:10][N:9]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:8]2)[C:5](=[O:21])[CH2:4][S:3]1.[Cl:22][C:23]1[CH:40]=[CH:39][C:26]([CH2:27][N:28]2[C:36]3[C:31](=[CH:32][C:33]([CH:37]=O)=[CH:34][CH:35]=3)[CH:30]=[N:29]2)=[C:25]([C:41]([F:44])([F:43])[F:42])[CH:24]=1>>[C:17]([O:16][C:14]([N:9]1[CH2:10][CH2:11][CH:12]([OH:13])[CH:7]([N:6]2[C:5](=[O:21])/[C:4](=[CH:37]/[C:33]3[CH:32]=[C:31]4[C:36](=[CH:35][CH:34]=3)[N:28]([CH2:27][C:26]3[CH:39]=[CH:40][C:23]([Cl:22])=[CH:24][C:25]=3[C:41]([F:44])([F:42])[F:43])[N:29]=[CH:30]4)/[S:3][C:2]2=[O:1])[CH2:8]1)=[O:15])([CH3:18])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehydeHCID 86659650HCID 86659650, compound

Product 1

HCID 86659684HCID 86659684, compound

Procedure

(5Z)-3-{5-[1-(4-chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester was prepared from 1,1-dimethylethyl trans-3-(2,4-dioxo-1,3-thiazolidin-3-yl)-4-hydroxypiperidine-1-carboxylate (from Example 270) and [4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 1) following General Procedure F1.

Sources & evidence

ORD record
ord-e685f4899ce449dd8ee24136f1d1434e
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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