Acetic Anhydride → N-(3-fluoro-2-methylphenyl)acetamide

HRID 2400940Notes

Reaction equation

HRID 2400940 reaction equation
[F:1][C:2]1[C:3]([CH3:9])=[C:4]([NH2:8])[CH:5]=[CH:6][CH:7]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C1(C)C=CC=CC=1>[F:1][C:2]1[C:3]([CH3:9])=[C:4]([NH:8][C:10](=[O:12])[CH3:11])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 2855533-Fluoro-2-methylaniline

Product 1

HCID 1489284N-(3-fluoro-2-methylphenyl)acetamide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
100 °C

Procedure

To the solution of 3-fluoro-2-methylphenylamine (40 mmol) in toluene (50 mL) was added acetic anhydride (47 mmol). The mixture was heated to 100° C. for 1 h, then concentrated to give N-(3-fluoro-2-methylphenyl)acetamide as an off-white solid.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-df6912b6e5594f2b870f9e0e3def4d16
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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