Bromine → N-(4-Bromo-3-fluoro-2-methylphenyl)acetamide

HRID 2400941Notes

Reaction equation

HRID 2400941 reaction equation
[F:1][C:2]1[C:3]([CH3:12])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:13]Br>C(O)(=O)C>[Br:13][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:11])[CH3:10])=[C:3]([CH3:12])[C:2]=1[F:1]

Participants

4

Reactant 2

HCID 24408BromineHCID 1489284N-(3-fluoro-2-methylphenyl)acetamide

Product 1

HCID 67123438N-(4-Bromo-3-fluoro-2-methylphenyl)acetamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of N-(3-Fluoro-2-methylphenyl)acetamide (39 mmol) in acetic acid (50 mL) was added bromine (40 mmol) in dropwise fashion. After stirring at rt for 2 days, the precipitated product was filtered, washed with water, and dried under high vacuum. N-(4-Bromo-3-fluoro-2-methylphenyl)acetamide was obtained as a white solid.

Workup

  1. filtrationthe precipitated product was filtered
  2. washwashed with water
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-821875d27e5f4b619e1cbcb7213e5098
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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