1-(5-Bromo-4-fluoroindazol-1-yl)ethanone → 5-Bromo-4-fluoro-1H-indazole

Participants

Reaction Steps

A suspension of 1-(5-Bromo-4-fluoroindazol-1-yl)ethanone (13 mmol) in 10% HCl (40 mL) and methanol (10 mL) was heated at reflux until clear (ca. 1 h). The hot solution was filtered, cooled and pH was neutralized by the addition of NaOH solution (3N). The resultant white precipitate was collected via filtration and the solid was dried in vacuum to give 5-bromo-4-fluoro-1H-indazole.

Provenance & Evidence