反应详情

A suspension of 1-(5-Bromo-4-fluoroindazol-1-yl)ethanone (13 mmol) in 10% HCl (40 mL) and methanol (10 mL) was heated at reflux until clear (ca. 1 h). The hot solution was filtered, cooled and pH was neutralized by the addition of NaOH solution (3N). The resultant white precipitate was collected via filtration and the solid was dried in vacuum to give 5-bromo-4-fluoro-1H-indazole.

1. temperaturewas heated
2. temperatureat reflux until clear (ca. 1 h)
3. filtrationThe hot solution was filtered
4. temperaturecooled
5. additionpH was neutralized by the addition of NaOH solution (3N)
6. filtrationThe resultant white precipitate was collected via filtration
7. customthe solid was dried in vacuum