Diazald → HCID 58919487, compound

HRID 2400949Notes

Reaction equation

HRID 2400949 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CC1C=CC(S(N([N:26]=[O:27])C)(=O)=O)=CC=1>C(Cl)Cl>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([N:26]=[O:27])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6628DiazaldHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 58919487HCID 58919487, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of piperazine-1-carboxylic acid tert-butyl ester (26 mmol) in DCM (130 mL) was added, in one portion, Diazald (4 eq.). After stirring at reflux for 12 h, the solution was cooled, concentrated and the residue was purified by flash chromatography (0-20% EtOAc/Heptane) to afford 4-nitrosopiperazine-1-carboxylic acid tert-butyl ester.

Workup

  1. temperatureat reflux for 12 h
  2. temperaturethe solution was cooled
  3. concentrationconcentrated
  4. customthe residue was purified by flash chromatography (0-20% EtOAc/Heptane)

Sources & evidence

ORD record
ord-6ca9e92d9a7f4229a696008e2cdee00f
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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