1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde → HCID 58530960, compound

HRID 2400955Notes

Reaction equation

HRID 2400955 reaction equation
[C:1]([O:5][C:6](=[O:15])[NH:7][N:8]1[C:12](=[O:13])[CH2:11][S:10][C:9]1=[O:14])([CH3:4])([CH3:3])[CH3:2].[Cl:16][C:17]1[CH:34]=[CH:33][C:20]([CH2:21][N:22]2[C:30]3[C:25](=[CH:26][C:27]([CH:31]=O)=[CH:28][CH:29]=3)[CH:24]=[N:23]2)=[C:19]([C:35]([F:38])([F:37])[F:36])[CH:18]=1>>[C:1]([O:5][C:6](=[O:15])[NH:7][N:8]1[C:12](=[O:13])/[C:11](=[CH:31]/[C:27]2[CH:26]=[C:25]3[C:30](=[CH:29][CH:28]=2)[N:22]([CH2:21][C:20]2[CH:33]=[CH:34][C:17]([Cl:16])=[CH:18][C:19]=2[C:35]([F:38])([F:36])[F:37])[N:23]=[CH:24]3)/[S:10][C:9]1=[O:14])([CH3:4])([CH3:2])[CH3:3].[NH2:7][N:8]1[C:12](=[O:13])/[C:11](=[CH:31]/[C:27]2[CH:26]=[C:25]3[C:30](=[CH:29][CH:28]=2)[N:22]([CH2:21][C:20]2[CH:33]=[CH:34][C:17]([Cl:16])=[CH:18][C:19]=2[C:35]([F:38])([F:36])[F:37])[N:23]=[CH:24]3)/[S:10][C:9]1=[O:14]

Participants

4

Reactant 2

HCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehydeHCID 86659693HCID 86659693, compound

Product 2

HCID 58530960HCID 58530960, compoundHCID 86659692HCID 86659692, compound

Procedure

(5Z)-{5-[1-(4-Chloro-2-trifluoromethylbenzyl)-1H-indazol-5-ylmethylene]-2,4-dioxothiazolidin-3-yl}carbamic acid tert-butyl ester was prepared from (2,4-dioxothiazolidin-3-yl)carbamic acid tert-butyl ester and [4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-carbaldehyde (from Example 1) following General Procedure F1. The Boc group was removed by TFA/DCM following General Procedure M to afford the title compound.

Workup

  1. customThe Boc group was removed by TFA/DCM following General Procedure M

Sources & evidence

ORD record
ord-fe78890b00884b55820210f700bd7d3a
Source dataset
uspto-grants-2014_08
Patent number
US08796256B2

Reaction notes

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