反应详情

温度

170 °C

A mixture of 1-[2,4-bis(trifluoromethyl)benzyl]-3-iodo-1H-indazol-5-carbaldehyde (2 mmol) and CuCN (5 mmol) in DMF (5 mL) was heated under microwave irradiation at 170° C. for 30 min. The mixture was partitioned between EtOAc and water. The EtOAc extracts were combined, washed with brine, dried (Na2SO4) and concentrated. The residue was purified by flash chromatography (EtOAc/hexanes 1:4 v/v) to afford 1-[2,4-bis(trifluoromethyl)benzyl]-3-cyano-1H-indazol-5-carbaldehyde as a white solid.

1. customThe mixture was partitioned between EtOAc and water
2. washwashed with brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated
5. customThe residue was purified by flash chromatography (EtOAc/hexanes 1:4 v/v)