反应详情

To a solution of 2-(trifluoromethyl)benzenesulfonyl chloride (5 g; 20.44 mmol; 1.00 eq.) in anhydrous THF (5.00 ml) was added a solution of 71 ml Ammonia in Ethanol 2M under nitrogen at room temperature. The reaction mixture was shaken for 20 h at room temperature. The solvent was evaporated and the residue redissolved in EtOAc (150 mL) and then washed with NH4Cl saturated aqueous solution (50 mL) and brine (50 mL). The organic layer was dried over MgSO4, filtered and the solvent evaporated to give the pure 2-(trifluoromethyl)benzenesulfonamide as a yellowish solid (4.6 g, 89% yield, 98.6% HPLC purity). This compound was utilized as such for the next reaction.

1. customThe solvent was evaporated
2. dissolutionthe residue redissolved in EtOAc (150 mL)
3. washwashed with NH4Cl saturated aqueous solution (50 mL) and brine (50 mL)
4. dry with materialThe organic layer was dried over MgSO4
5. filtrationfiltered
6. customthe solvent evaporated