N-Methylaniline → HCID 11960235, compound

HRID 2401048Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[C:17]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24]Cl)=[CH:20][CH:19]=3)=[N:16][CH:15]=[CH:14][N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:26][NH:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[C:17]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24][N:27]([CH3:26])[C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[CH:20][CH:19]=3)=[N:16][CH:15]=[CH:14][N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7515N-Methylaniline

HCID 67413480HCID 67413480, compound

Product 1

HCID 11960235HCID 11960235, compoundYield 76%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from 4-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide, and N-methyl-aniline, the title compound was isolated as a yellow solid in 76% yield (96% purity by HPLC).

Sources & evidence

ORD record: ord-6d9d85b6609e4a198861890813171161
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08796280B2

Reaction notes

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