4-(Methylamino)benzonitrile → HCID 57444240, compound

HRID 2401052Notes

Reaction equation

HRID 2401052 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17])=[N:11][CH:12]=[CH:13][N:14]=2)=[CH:5][CH:4]=1.[CH3:29][NH:30][C:31]1[CH:38]=[CH:37][C:34]([C:35]#[N:36])=[CH:33][CH:32]=1>>[C:35]([C:34]1[CH:37]=[CH:38][C:31]([N:30]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3[C:10]([NH:15][S:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[C:25]([F:28])([F:27])[F:26])(=[O:18])=[O:17])=[N:11][CH:12]=[CH:13][N:14]=3)=[CH:5][CH:4]=2)[CH3:29])=[CH:32][CH:33]=1)#[N:36]

Participants

3

Reactant 2

HCID 109645514-(Methylamino)benzonitrileHCID 57444250N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzenesulfonamide2×

Product 1

HCID 57444240HCID 57444240, compoundYield 71%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(trifluoromethyl)benzene sulfonamide (Intermediate 9), and 4-(N-methylamino)benzonitrile, the title compound was isolated as a yellow solid in 71% yield (94% purity by HPLC).

Sources & evidence

ORD record
ord-231564c8854443c8a1a45405c6cd2c14
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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