2,4-difluoro-N-methylaniline → HCID 11960560, compound

HRID 2401072Notes

Reaction equation

HRID 2401072 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24]Cl)=[CH:20][CH:19]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9].[F:26][C:27]1[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:28]=1[NH:29][CH3:30]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]1[C:17]([C:18]2[CH:19]=[CH:20][C:21]([CH2:24][N:29]([C:28]3[CH:31]=[CH:32][C:33]([F:35])=[CH:34][C:27]=3[F:26])[CH3:30])=[CH:22][CH:23]=2)=[N:16][CH:15]=[CH:14][N:13]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 27370232,4-difluoro-N-methylanilineHCID 574442542-chloro-N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}benzenesulfonamide2×

Product 1

HCID 11960560HCID 11960560, compoundYield 77%

Procedure

Following the general method as outlined in Example 1 (Method B), starting from N-{3-[4-(chloromethyl)phenyl]pyrazin-2-yl}-2-(chloro) benzenesulfonamide (Intermediate 8), and 2,4-difluoro-N-methylaniline, the title compound was isolated as a yellow solid in 77% yield (92% purity by HPLC).

Sources & evidence

ORD record
ord-be760efe65ab47e29f947cf1498a64d3
Source dataset
uspto-grants-2014_08
Patent number
US08796280B2

Reaction notes

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