HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(+)-2-Methylpiperidine → (S)-3-((S)-2-Methyl-piperidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(+)-2-Methylpiperidine | HCID 6427443 | — |
| Reactant | (R)-tert-Butyl 3-(tosyloxy)pyrrolidine-1-carboxylate | HCID 23560883 | — |
| Reactant | (2S,3'S)-2-Methyl-[1,3]bipyrrolidinyl-1'-carboxylic acid tert-butyl ester | HCID 59401846 | — |
| Product | (S)-3-((S)-2-Methyl-piperidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 58468060 | 38% |
Reaction Steps
The title compound was prepared in a manner substantially the same as intermediate (xi), (2S,3′S)-2-methyl-[1,3′]bipyrrolidinyl-1′-carboxylic acid tert-butyl ester by condensing 3-(3R)-(toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (5 g) with (S)-2-methyl-piperidine to obtain 1.5 g (38% yield) of the title compound as a beige oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08796278B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-9dc292d853294a14b8ea211bdd7919c6 |
| Source note | uspto-grants-2014_08 |