4-(2-Oxoethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester → HCID 71280635, compound

HRID 2401121Notes

Reaction equation

HRID 2401121 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([CH2:19][CH:20]=O)[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:22][C:23]1[C:28]([NH2:29])=[CH:27][CH:26]=[C:25]([N:30]2[CH2:34][CH2:33][C@@H:32]([N:35]3[CH2:39][CH2:38][CH2:37][C@@H:36]3[CH3:40])[CH2:31]2)[N:24]=1>>[CH2:1]([O:3][C:4]([C:6]1([CH2:19][CH2:20][NH:29][C:28]2[C:23]([CH3:22])=[N:24][C:25]([N:30]3[CH2:34][CH2:33][C@@H:32]([N:35]4[CH2:39][CH2:38][CH2:37][C@@H:36]4[CH3:40])[CH2:31]3)=[CH:26][CH:27]=2)[CH2:7][CH2:8][N:9]([C:12]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:13])[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 584784234-(2-Oxoethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl esterHCID 674804612-methyl-6-[(3R)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]pyridin-3-amine

Product 1

HCID 71280635HCID 71280635, compound

Procedure

The title compound was synthesized in essentially the same manner using the procedures as set forth in Step 1 of Example 1, by condensing 4-(2-oxo-ethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (66 mg, 0.22 mmol) and 2-methyl-6-((2S,3′R)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-pyridin-3-ylamine to obtain 111 mg of a crude solid, which was used without purification.

Sources & evidence

ORD record
ord-b5127db94488494a8af9cc470e7325dd
Source dataset
uspto-grants-2014_08
Patent number
US08796278B2

Reaction notes

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