Hydrochloric Acid → HCID 54591073, compound

HRID 2401132Notes

Reaction equation

HRID 2401132 reaction equation
C(OC([N:8]1[CH2:36][CH2:35][C:11]2([C:15](=[O:16])[N:14]([C:17]3[C:18]([CH3:34])=[N:19][C:20]([N:23]4[CH2:27][CH2:26][C@@H:25]([N:28]5[CH2:32][CH2:31][CH2:30][C@@H:29]5[CH3:33])[CH2:24]4)=[CH:21][CH:22]=3)[CH2:13][CH2:12]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:37]>CO.CCO>[ClH:37].[CH3:34][C:18]1[C:17]([N:14]2[CH2:13][CH2:12][C:11]3([CH2:35][CH2:36][NH:8][CH2:9][CH2:10]3)[C:15]2=[O:16])=[CH:22][CH:21]=[C:20]([N:23]2[CH2:27][CH2:26][C@@H:25]([N:28]3[CH2:32][CH2:31][CH2:30][C@@H:29]3[CH3:33])[CH2:24]2)[N:19]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54590987HCID 54590987, compound

Product 1

HCID 54591073HCID 54591073, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

To a solution of 2-[2-methyl-6-((2S,3′R)-2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-pyridin-3-yl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (50 mg, 0.1 mmol) in methanol (2 mL) was added a saturated solution of HCl in EtOH (2 mL) and stirred the resulting mixture for 20 hours. Concentrated the reaction mixture and dried under high vacuum to afford 42 mg (97% yield) of the title compound as a solid.

Workup

  1. concentrationConcentrated the reaction mixture
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-a7c17758f92145e48a37c16ce6215241
Source dataset
uspto-grants-2014_08
Patent number
US08796278B2

Reaction notes

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